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Deoxygenative Borylation of Secondary and Tertiary Alcohols
Author(s) -
Friese Florian W.,
Studer Armido
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201904028
Subject(s) - borylation , chemistry , tertiary alcohols , functional group , catalysis , silylation , substrate (aquarium) , radical , scope (computer science) , organic chemistry , combinatorial chemistry , photochemistry , biology , computer science , aryl , alkyl , ecology , polymer , programming language
Two different approaches for the deoxygenative radical borylation of secondary and tertiary alcohols are presented. These transformations either proceed through a metal‐free silyl‐radical‐mediated pathway or utilize visible‐light photoredox catalysis. Readily available xanthates or methyl oxalates are used as radical precursors. The reactions show broad substrate scope and high functional‐group tolerance, and are conducted under mild and practical conditions.