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Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid
Author(s) -
Meyer Claudio F.,
Hell Sandrine M.,
Misale Antonio,
Trabanco Andrés A.,
Gouverneur Véronique
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201903801
Subject(s) - reagent , regioselectivity , tetrahydrofuran , functional group , combinatorial chemistry , chemistry , scalability , visible spectrum , organic chemistry , computer science , materials science , catalysis , operating system , optoelectronics , solvent , polymer
A facile method for the regioselective hydrodifluoromethylation of alkenes is reported using difluoroacetic acid and phenyliodine(III) diacetate in tetrahydrofuran under visible‐light activation. This metal‐free approach stands out as it uses inexpensive reagents, does not require a photocatalyst, and displays broad functional group tolerance. The procedure is also operationally simple and scalable, and provides access in one step to high‐value building blocks for application in medicinal chemistry.