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Functionalized h‐BN Nanosheets as a Theranostic Platform for SERS Real‐Time Monitoring of MicroRNA and Photodynamic Therapy
Author(s) -
Liu Jia,
Zheng Tingting,
Tian Yang
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201902776
Subject(s) - photodynamic therapy , materials science , nanotechnology , boron nitride , hexagonal boron nitride , in vivo , conjugated system , raman spectroscopy , molecular beacon , oligonucleotide , chemistry , dna , organic chemistry , polymer , biochemistry , graphene , microbiology and biotechnology , physics , optics , composite material , biology
Traditional therapeutic and diagnostic tools exhibit serious side effects, poor selectivity, and sensitivity. Herein, a multifunctional CuPc@HG@BN theranostic platform composed of hexagonal boron nitride nanosheets (h‐BNNS), conjugated DNA oligonucleotide, and copper(II) phthalocyanine (CuPc) was developed in which the CuPc molecule played double key roles in photodynamic therapy (PDT) as well as in situ monitoring and imaging of miR‐21 by surface‐enhanced Raman spectroscopy (SERS). Owing to the designed circle amplification of miRNA and high SERS effects of CuPc on h‐BNNS, miR‐21 responsive concentration was achieved as low as 0.7 f m in live cells. Both in vitro and in vivo data demonstrated that the integrated nanoplatform showed remarkable enhancement in PDT efficiency with minimized damage to the normal tissues. The developed probe was also successfully utilized for early monitoring and guiding the early therapy, realizing tumor elimination.