Cover Picture: Assessment of a Large Enzyme–Drug Complex by Proton‐Detected Solid‐State NMR Spectroscopy without Deuteration (Angew. Chem. Int. Ed. 17/2019) | Zendy

Vasa Suresh K. | Zendy; Singh Himanshu | Zendy; Grohe Kristof | Zendy; Linser Rasmus | Zendy

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Cover Picture: Assessment of a Large Enzyme–Drug Complex by Proton‐Detected Solid‐State NMR Spectroscopy without Deuteration (Angew. Chem. Int. Ed. 17/2019)

Author(s) -

Vasa Suresh K.,

Singh Himanshu,

Grohe Kristof,

Linser Rasmus

Publication year - 2019

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201902502

Subject(s) - magic angle spinning , solid state nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , spectroscopy , spinning , solid state , molecule , deuterium , chemistry , small molecule , magic angle , crystallography , materials science , nanotechnology , nuclear magnetic resonance , physics , stereochemistry , atomic physics , biochemistry , organic chemistry , quantum mechanics , polymer chemistry

Moving pictures of proteins were obtained by solid‐state NMR spectroscopy of small amounts of non‐deuterated sample by employing fast magic‐angle‐spinning rotors. From a consideration of previous approaches involving deuteration, this preview by R. Linser and co‐workers forecasts a largely facilitated sample preparation even for demanding future targets. In their Communication on page 5758 ff., they describe comprehensive insight into the structure and dynamics of a complex between a 29 kDa enzyme and a small‐molecule inhibitor.

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