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Controlled Release of a Micelle Payload via Sequential Enzymatic and Bioorthogonal Reactions in Living Systems
Author(s) -
Porte Karine,
Renoux Brigitte,
Péraudeau Elodie,
Clarhaut Jonathan,
Eddhif Balkis,
Poinot Pauline,
Gravel Edmond,
Doris Eric,
Wijkhuisen Anne,
Audisio Davide,
Papot Sébastien,
Taran Frédéric
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201902137
Subject(s) - bioorthogonal chemistry , micelle , chemistry , combinatorial chemistry , click chemistry , payload (computing) , enzyme , nanotechnology , computer science , biochemistry , materials science , organic chemistry , aqueous solution , computer network , network packet
A bioorthogonal approach is explored to release the content of nanoparticles on demand. Exploiting our recently described click‐and‐release technology, we developed a new generation of cleavable micelles able to disassemble through a sequential enzymatic and bioorthogonal activation process. Proof‐of‐concept experiments showed that this new approach could be successfully used to deliver the substances encapsulated into micelles in living cells as well as in mice by two complementary targeted strategies.