Palladium‐Catalyzed Decarboxylative γ‐Arylation for the Synthesis of Tetrasubstituted Chiral Allenes | Zendy

Scheipers Ina | Zendy; MückLichtenfeld Christian | Zendy; Studer Armido | Zendy

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Palladium‐Catalyzed Decarboxylative γ‐Arylation for the Synthesis of Tetrasubstituted Chiral Allenes

Author(s) -

Scheipers Ina,

MückLichtenfeld Christian,

Studer Armido

Publication year - 2019

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201901848

Subject(s) - palladium , catalysis , decarboxylation , aryl , chemistry , chirality (physics) , allene , coupling (piping) , organic chemistry , combinatorial chemistry , materials science , physics , chiral symmetry , alkyl , nambu–jona lasinio model , metallurgy , quark , quantum mechanics

An enantiospecific palladium‐catalyzed decarboxylative coupling of acyclic β,γ‐alkynoic acids with various aryl iodides to chiral tetrasubstituted allenes is described. The coupling reaction comprises a decarboxylative γ‐palladation of α,α‐disubstituted carboxylic acids to provide the tetrasubstituted allenes with complete point‐to‐axial chirality transfer in excellent yields.

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