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Intermolecular Radical C(sp 3 )−H Amination under Iodine Catalysis
Author(s) -
Bosnidou Alexandra E.,
Muñiz Kilian
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201901673
Subject(s) - amination , intermolecular force , chemistry , iodine , catalysis , organic synthesis , organic chemistry , combinatorial chemistry , molecule
The direct amination of aliphatic C−H bonds has remained one of the most tantalizing transformations in organic chemistry. Herein, we report on a unique catalyst system, which enables the elusive intermolecular C(sp 3 )−H amination. This practical synthetic strategy provides access to aminated building blocks and fosters innovative multiple C−H amination within a new approach to aminated heterocycles. The synthetic utility is demonstrated by the synthesis of four relevant pharmaceuticals.