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Continuous‐Flow Electrosynthesis of Benzofused S‐Heterocycles by Dehydrogenative C−S Cross‐Coupling
Author(s) -
Huang Chong,
Qian XiangYang,
Xu HaiChao
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201901610
Subject(s) - electrosynthesis , electrolysis , chemistry , oxidizing agent , flow chemistry , reagent , combinatorial chemistry , continuous flow , intramolecular force , electrolytic cell , transition metal , catalysis , electrochemistry , electrolyte , organic chemistry , electrode , biochemical engineering , engineering
Reported herein is the synthesis of benzofused six‐membered S‐heterocycles by intramolecular dehydrogenative C−S coupling using a modular flow electrolysis cell. The continuous‐flow electrosynthesis not only ensures efficient product formation, but also obviates the need for transition‐metal catalysts, oxidizing reagents, and supporting electrolytes. Reaction scale‐up is conveniently achieved through extended electrolysis without changing the reaction conditions and equipment.