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A C 5 N 2 Nanoparticle Based Direct Nucleus Delivery Platform for Synergistic Cancer Therapy
Author(s) -
Chen Weihua,
Liu Jianhua,
Wang Ying,
Jiang Chunhuan,
Yu Bin,
Sun Zhen,
Lu Lehui
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201900884
Subject(s) - photothermal therapy , intracellular , chemistry , nucleus , biophysics , cell , doxorubicin , endosome , nanotechnology , nanoparticle , cancer cell , nanomedicine , cancer therapy , cell membrane , propidium iodide , nuclear pore , cancer research , cancer , programmed cell death , materials science , biochemistry , microbiology and biotechnology , apoptosis , biology , medicine , cytoplasm , chemotherapy
Intracellular targeting has the same potential as tissue targeting to increase therapy efficacy, especially for drugs that are toxic to DNA. By adjusting intracellular traffic, we developed a novel direct‐nucleus‐delivery platform based on C 5 N 2 nanoparticles (NPs). Supramolecular interactions of C 5 N 2 NPs with the cell membrane enhanced cell uptake; abundant edge amino groups promoted fast and effective rupture of early endosomes; and the appropriate size of the NPs was also crucial for size‐dependent nuclear entry. As a proof of concept, the platform was not only suitable for the effective delivery of molecular drugs/dyes (doxorubicin, hydroxycamptothecine, and propidium iodide) and MnO 2 nanoparticles to the nucleus, but was also photoresponsive for nucleus‐targeting photothermal therapy (PTT) and photodynamic therapy (PDT) to further greatly increase anticancer efficacy. This strategy might open the door to a new generation of nuclear‐targeted enhanced anticancer therapy.