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Solvent Adaptive Dynamic Metal‐Organic Soft Hybrid for Imaging and Biological Delivery
Author(s) -
Samanta Debabrata,
Roy Syamantak,
Sasmal Ranjan,
Saha Nilanjana Das,
K R Pradeep,
Viswanatha Ranjani,
Agasti Sarit S.,
Maji Tapas Kumar
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201900692
Subject(s) - solvent , linker , chemistry , drug delivery , amphiphile , materials science , organic chemistry , polymer , computer science , copolymer , operating system
Abstract A solvent responsive dynamic nanoscale metal‐organic framework (NMOF) [Zn( 1 a )(H 2 O) 2 ] has been devised based on the self‐assembly of Zn II and asymmetric bola‐amphiphilic oligo ‐( p ‐phenyleneethynylene) (OPE) dicarboxylate linker 1 a having dodecyl and triethyleneglycolmonomethylether (TEG, polar) side chains. In THF solvent, NMOF showed nanovesicular morphology ( NMOF‐1 ) with surface decorated dodecyl chains. In water and methanol, NMOF exhibited inverse‐nanovesicle ( NMOF‐2 ) and nanoscroll ( NMOF‐3 ) morphology, respectively, with surface projected TEG chains. The pre‐formed NMOFs also unveiled reversible solvent responsive transformation of different morphologies. The flexible NMOF showed cyan emission and no cytotoxicity, allowing live cell imaging. Cisplatin (14.4 wt %) and doxorubicin (4.1 wt %) were encapsulated in NMOF‐1 by non‐covalent interactions and, in vitro and in vivo drug release was studied. The drug loaded NMOFs exhibited micromolar cytotoxicity.