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Nickel‐Catalyzed Asymmetric Reductive Diarylation of Vinylarenes
Author(s) -
Anthony David,
Lin Qiao,
Baudet Judith,
Diao Tianning
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201900228
Subject(s) - nickel , catalysis , reagent , combinatorial chemistry , aryl , ligand (biochemistry) , chemistry , stoichiometry , reductive elimination , coupling (piping) , organic chemistry , materials science , metallurgy , biochemistry , receptor , alkyl
A nickel‐catalyzed asymmetric diarylation reaction of vinylarenes enables the preparation of chiral α,α,β‐triarylated ethane scaffolds, which exist in a number of biologically active molecules. The use of reducing conditions with aryl bromides as coupling partners obviates the need for stoichiometric organometallic reagents and tolerates a broad range of functional groups. The application of an N ‐oxyl radical as a ligand to a nickel catalyst represents a novel approach to facilitate nickel‐catalyzed cross‐coupling reactions.