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Inside Cover: Bioinspired Engineering of a Multivalent Aptamer‐Functionalized Nanointerface to Enhance the Capture and Release of Circulating Tumor Cells (Angew. Chem. Int. Ed. 8/2019)
Author(s) -
Song Yanling,
Shi Yuanzhi,
Huang Mengjiao,
Wang Wei,
Wang Yang,
Cheng Jie,
Lei Zhichao,
Zhu Zhi,
Yang Chaoyong
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201900205
Subject(s) - aptamer , circulating tumor cell , cover (algebra) , chemistry , nanotechnology , biophysics , materials science , combinatorial chemistry , microbiology and biotechnology , biology , engineering , cancer , mechanical engineering , metastasis , genetics
An aptamer‐functionalized nanointerface for capture and release of circulating tumor cells (CTCs) is described by C. Yang et al. in their Communication on page 2236 ff. Inspired by the prey capture mechanism of the octopus, an aptamer‐tailed octopus chip was engineered, which combines a multivalence effect to enhance binding affinity, size‐selective enhancement of cell–micropillar collisions to improve capture efficiency, and a thiol–gold interface for nondestructive release of CTCs for downstream analysis.