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Assembled Vitamin B2 Nanocrystals with Optical Waveguiding and Photosensitizing Properties for Potential Biomedical Application
Author(s) -
Fei Jinbo,
Dai Luru,
Gao Fuping,
Zhao Jie,
Li Junbai
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201900124
Subject(s) - nanorod , photodynamic therapy , biomolecule , nanotechnology , materials science , nanostructure , nanocrystal , in vivo , vitamin , chemistry , biochemistry , biology , organic chemistry , microbiology and biotechnology
Great success has been achieved in recent years in the development of synthetic or assembled nanobiomaterials. Among these, biomolecule‐based nanoarchitectures with special optical property are of particular interest. Here, we demonstrate that vitamin B 2 nanocrystals assembled as nanorods can be obtained with precise control. Excitingly, such one‐dimensional nanostructures not only exhibit intrinsic optical waveguiding properties but also the ability to sensitize oxygen to produce reactive oxygen species. With these properties, we applied the obtained vitamin B 2 nanorods under remotely localized light illumination into single tumour cells in vitro for anticancer photodynamic therapy. Further, vitamin B 2 nanorods were explored for in vivo photodynamic therapy by using a tumour model. With such bionanostructures, new features and functions of vitamin B 2 and its derivatives have been developed.