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A Polymer Coating Transfer Enrichment Method for Direct Mass Spectrometry Analysis of Lipids in Biofluid Samples
Author(s) -
Zhang Wenpeng,
Chiang Spencer,
Li Zishuai,
Chen Qinhua,
Xia Yu,
Ouyang Zheng
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201900011
Subject(s) - chemistry , chromatography , mass spectrometry , coating , polymer , analytical chemistry (journal) , organic chemistry
A porous polymer coating transfer enrichment method is developed for the direct mass spectrometry (MS) analysis of lipids. The enrichment is fast (ca. 1 min) and enables the profiling and quantitation of lipids in small‐volume biofluid samples. Coupled with a photochemical Paternò–Büchi reaction, this method enables the fast determination of lipid structure at the C=C location level and point‐of‐care lipid biomarker analysis.