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Frontispiece: In Situ Cyclization of Native Proteins: Structure‐Based Design of a Bicyclic Enzyme
Author(s) -
PelayGimeno Marta,
Bange Tanja,
Hennig Sven,
Grossmann Tom N.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201883561
Subject(s) - bicyclic molecule , linker , in situ , enzyme , protein engineering , chemistry , stereochemistry , thermal stability , biochemistry , organic chemistry , computer science , operating system
Protein Engineering . In their Communication on page 11164 ff., T. N. Grossmann et al. report on the generation of a bicyclic enzyme with a triselectrophilic linker, which leads to strongly increased stability towards thermal denaturation.