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Inside Cover: A Pretreatment‐Free, Polymer‐Based Platform Prepared by Molecular Imprinting and Post‐Imprinting Modifications for Sensing Intact Exosomes (Angew. Chem. Int. Ed. 6/2019)
Author(s) -
Mori Kisho,
Hirase Mitsuhiro,
Morishige Takahiro,
Takano Eri,
Sunayama Hirobumi,
Kitayama Yukiya,
Inubushi Sachiko,
Sasaki Ryohei,
Yashiro Masakazu,
Takeuchi Toshifumi
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201814225
Subject(s) - microvesicles , imprinting (psychology) , molecular imprinting , fluorescence , chemistry , nanotechnology , exosome , polymer , molecule , nanoparticle , biophysics , materials science , selectivity , biology , catalysis , biochemistry , microrna , organic chemistry , gene , physics , quantum mechanics
A pretreatment‐free fluorescence‐based sensing platform for intact exosomes was prepared by molecular imprinting and post‐imprinting modifications. In their Communication on page 1612 ff., T. Takeuchi et al. show that by introducing antibodies and fluorescent reporter molecules only inside binding nanocavities, highly sensitive detection of exosomes without pretreatment is enabled. This exosome sensing system discriminated between normal exosomes and those originating from prostate cancer.