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Alkyllithium Compounds Bearing Electrophilic Functional Groups: A Flash Chemistry Approach
Author(s) -
Nagaki Aiichiro,
Yamashita Hiroki,
Hirose Katsuyuki,
Tsuchihashi Yuta,
Yoshida Junichi
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201814088
Subject(s) - electrophile , chemistry , flash (photography) , bearing (navigation) , functional group , reactivity (psychology) , microreactor , combinatorial chemistry , flow chemistry , organic chemistry , computer science , medicine , art , polymer , alternative medicine , pathology , artificial intelligence , visual arts , catalysis
Flash chemistry based on flow microreactor systems allowed alkyllithiums bearing electrophilic functional groups to be successfully generated and used for subsequent reactions. The series of reactions with high reactivity was achieved by extremely accurate control over residence time in a controlled and selective manner.