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A Single‐Atom Nanozyme for Wound Disinfection Applications
Author(s) -
Xu Bolong,
Wang Hui,
Wang Weiwei,
Gao Lizeng,
Li Shanshan,
Pan Xueting,
Wang Hongyu,
Yang Hailong,
Meng Xiangqin,
Wu Qiuwen,
Zheng Lirong,
Chen Shenming,
Shi Xinghua,
Fan Kelong,
Yan Xiyun,
Liu Huiyu
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201813994
Subject(s) - catalysis , zinc , density functional theory , atom (system on chip) , zeolitic imidazolate framework , chemistry , imidazolate , homogeneous , combinatorial chemistry , nanomaterials , nanotechnology , materials science , photochemistry , computational chemistry , organic chemistry , metal organic framework , embedded system , physics , adsorption , computer science , thermodynamics
Single‐atom catalysts (SACs), as homogeneous catalysts, have been widely explored for chemical catalysis. However, few studies focus on the applications of SACs in enzymatic catalysis. Herein, we report that a zinc‐based zeolitic‐imidazolate‐framework (ZIF‐8)‐derived carbon nanomaterial containing atomically dispersed zinc atoms can serve as a highly efficient single‐atom peroxidase mimic. To reveal its structure–activity relationship, the structural evolution of the single‐atom nanozyme (SAzyme) was systematically investigated. Furthermore, the coordinatively unsaturated active zinc sites and catalytic mechanism of the SAzyme are disclosed using density functional theory (DFT) calculations. The SAzyme, with high therapeutic effect and biosafety, shows great promises for wound antibacterial applications.