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Cover Picture: Bioinspired Radical Stetter Reaction: Radical Umpolung Enabled by Ion‐Pair Photocatalysis (Angew. Chem. Int. Ed. 4/2019)
Author(s) -
Morack Tobias,
MückLichtenfeld Christian,
Gilmour Ryan
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201813835
Subject(s) - umpolung , chemoselectivity , photocatalysis , aldehyde , chemistry , combinatorial chemistry , organic chemistry , photochemistry , catalysis , nucleophile
A bioinspired radical Stetter reaction of α‐keto acids and aldehydes has been designed that is contingent on a formal “radical umpolung” concept. In their Communication on page 1208 ff., R. Gilmour and co‐workers synergise organo‐ and photocatalysis activation principles to expand the mechanistic and synthetic scope of the classic Stetter reaction to include α,β‐unsaturated aldehyde acceptors, and thus solve a longstanding chemoselectivity problem.