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Back Cover: Chemo‐ and Regioselective Dihydroxylation of Benzene to Hydroquinone Enabled by Engineered Cytochrome P450 Monooxygenase (Angew. Chem. Int. Ed. 3/2019)
Author(s) -
Zhou Hangyu,
Wang Binju,
Wang Fei,
Yu Xiaojuan,
Ma Lixin,
Li Aitao,
Reetz Manfred T.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201813834
Subject(s) - monooxygenase , hydroquinone , dihydroxylation , regioselectivity , chemistry , directed evolution , cytochrome p450 , benzene , stereochemistry , biocatalysis , cytochrome , transformation (genetics) , combinatorial chemistry , mutant , enzyme , biochemistry , organic chemistry , reaction mechanism , catalysis , enantioselective synthesis , gene
The unique enzymatic one‐pot dihydroxylation of benzene to hydroquinone can be achieved as described by A. Li, M. T. Reetz et al. in their Communication on page 764 ff. A mutant of a cytochrome P450 monooxygenase obtained by a semirational protein engineering strategy catalyzes this challenging transformation with no overoxidation, enabling, among other things, the cascade synthesis of biologically active arbutin by a constructed Escherichia coli designer cell system.