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Regiodivergent Hydroaminoalkylation of Alkynes and Allenes by a Combined Rhodium and Photoredox Catalytic System
Author(s) -
Zheng Jun,
Breit Bernhard
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201813646
Subject(s) - regioselectivity , rhodium , electrophile , allylic rearrangement , catalysis , chemistry , combinatorial chemistry , organic chemistry
A rhodium/photoredox dual catalyzed regiodivergent α‐allylation of amines is described. As an atom‐economic and efficient method, alkynes and allenes are used as allylic electrophile surrogates in this novel protocol. With different reaction conditions, synthetically useful branched or linear homoallylic amines could be synthesized in good to excellent yields and regioselectivity. This straightforward strategy complements the traditional transition‐metal catalyzed allylation reactions.