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Asymmetric Alkenylation of Enones and Imines Enabled by A Highly Efficient Aryl to Vinyl 1,4‐Rhodium Migration
Author(s) -
Zhang ShuSheng,
Hu TianJiao,
Li MengYao,
Song YiKang,
Yang XiaoDi,
Feng ChenGuo,
Lin GuoQiang
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201813585
Subject(s) - rhodium , aryl , chemistry , combinatorial chemistry , catalysis , polymer chemistry , organic chemistry , alkyl
The asymmetric rhodium‐catalyzed alkenylation of enones and imines with arylboronic acids has been developed. A highly controllable aryl to vinyl 1,4‐rhodium migration is the key step. Stereodefined vinyl moieties were installed in excellent enantioselectivies for most examined examples. DFT calculations reveal that the driving force of this rhodium migration is a kinetically favored process.