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Inside Back Cover: Coiled‐Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection (Angew. Chem. Int. Ed. 52/2018)
Author(s) -
Mueller Carolin,
Grossmann Tom N.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201813484
Subject(s) - coiled coil , cover (algebra) , peptide , molecular beacon , electromagnetic coil , chemistry , biophysics , physics , biochemistry , biology , engineering , mechanical engineering , oligonucleotide , quantum mechanics , dna
Coiled‐coil peptide beacons consist of a central binding sequence (yellow) and two flanking coiled‐coil‐forming peptides (red). Their hairpin‐like, closed conformation is opened upon receptor (gray) binding. In their Communication on page 17079 ff., C. Mueller and T. N. Grossmann introduce this novel molecular switch and report its use for protein detection.