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Ultra‐Fast Synthesis of Multivalent Radical Nanoparticles by Ring‐Opening Metathesis Polymerization‐Induced Self‐Assembly
Author(s) -
Le Dao,
Dilger Marco,
Pertici Vincent,
Diabaté Silvia,
Gigmes Didier,
Weiss Carsten,
Delaittre Guillaume
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201813434
Subject(s) - copolymer , nitroxide mediated radical polymerization , chemistry , amphiphile , polymer chemistry , polymerization , nanoparticle , radical polymerization , monomer , biocompatibility , self assembly , organic chemistry , materials science , nanotechnology , polymer
We report the straightforward, time‐efficient synthesis of radical core–shell nanoparticles (NPs) by polymerization‐induced self‐assembly. A nitroxide‐containing hydrophilic macromolecular precursor was prepared by ring‐opening metathesis copolymerization of norbornenyl derivatives of TEMPO and oligoethylene glycol and was chain‐extended in situ with norbornene in ethanolic solution, leading to simultaneous amphiphilic block copolymer formation and self‐assembly. Without any intermediate purification from the monomers to the block copolymers, radical NPs with tunable diameters ranging from 10 to 110 nm are obtained within minutes at room temperature. The high activity of the radical NPs as chemoselective and homogeneous, yet readily recyclable catalysts is demonstrated through oxidation of a variety of alcohols and recovery by simple centrifugation. Furthermore, the NPs show biocompatibility and antioxidant activity in vitro.