Base‐Mediated Defluorosilylation of C(sp 2 )−F and C(sp 3 )−F Bonds | Zendy

Liu XiangWei | Zendy; Zarate Cayetana | Zendy; Martin Ruben | Zendy

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Base‐Mediated Defluorosilylation of C(sp 2 )−F and C(sp 3 )−F Bonds

Author(s) -

Liu XiangWei,

Zarate Cayetana,

Martin Ruben

Publication year - 2019

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201813294

Subject(s) - catalysis , context (archaeology) , bond cleavage , chemistry , heteroatom , base (topology) , base metal , metal , surface modification , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , materials science , ring (chemistry) , metallurgy , mathematics , paleontology , mathematical analysis , welding , biology

The ability to selectively forge C–heteroatom bonds by C−F scission is typically accomplished by metal catalysts, specialized ligands and/or harsh reaction conditions. Described herein is a base‐mediated defluorosilylation of unactivated C(sp 2 )−F and C(sp 3 )−F bonds that obviates the need for metal catalysts. This protocol is characterized by its simplicity, mild reaction conditions, and wide scope, even within the context of late‐stage functionalization, constituting a complementary approach to existing C−Si bond‐forming protocols.

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