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A Freezing‐Induced Turn‐On Imaging Modality for Real‐Time Monitoring of Cancer Cells in Cryosurgery
Author(s) -
He Zhiyuan,
Liu Pai,
Zhang Shizhong,
Yan Jie,
Wang Mengni,
Cai Zhengxu,
Wang Jianjun,
Dong Yuping
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201813239
Subject(s) - cryosurgery , biocompatibility , modality (human–computer interaction) , cancer , chemistry , fluorescence , nanotechnology , biomedical engineering , materials science , medicine , radiology , computer science , optics , human–computer interaction , physics , organic chemistry
Cryosurgery has attracted much attention for the treatment of tumors owing to its clear advantages. However, determining the volume of frozen tissues in real‐time remains a challenge, which greatly lowers the therapeutic efficacy of cryosurgery and hinders its broad application for the treatment of cancers. Herein, we report a freezing‐induced turn‐on strategy for the selective real‐time imaging of frozen cancer cells. As a type of aggregation‐induced emission (AIE) fluorogen, TABD‐Py molecules interact specifically with ice crystals and form aggregates at the ice/water interface. Consequently, bright fluorescent emission appears upon freezing. TABD‐Py molecules are enriched mostly in the cancer cells and exhibit high biocompatibility as well as low cytotoxicity; therefore, a freezing‐induced turn‐on imaging modality for cryosurgery is developed, which will certainly maximize the therapeutic efficacy of cryosurgery in treating tumors.