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Enantioselective Aluminum‐Free Alkene Hydroarylations through C−H Activation by a Chiral Nickel/JoSPOphos Manifold
Author(s) -
Loup Joachim,
Müller Valentin,
Ghorai Debasish,
Ackermann Lutz
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201813191
Subject(s) - enantioselective synthesis , nickel , alkene , reagent , catalysis , chemistry , selectivity , stereochemistry , combinatorial chemistry , organic chemistry
Highly enantioselective nickel‐catalyzed alkene endo ‐hydroarylations were accomplished with full selectivity by organometallic C−H activation. The asymmetric assembly of chiral six‐membered scaffolds proved viable in the absence of pyrophoric organoaluminum reagents within an unprecedented nickel/JoSPOphos manifold.
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