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Acetaldehyde Silyl Enol Ethers in Enantioselective Mukaiyama Aldol Reactions: Enzyme‐Like Organocatalysis in Action
Author(s) -
Dell'Amico Luca,
Zanardi Franca
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201812964
Subject(s) - enantioselective synthesis , aldol reaction , enol , acetaldehyde , chemistry , silylation , organocatalysis , organic chemistry , catalysis , substrate (aquarium) , enzyme catalysis , biology , ecology , ethanol
Touched for the very first time ! It is herein highlighted how acetaldehyde silyl enol ethers undergo enantioselective Mukaiyama aldol reaction with aliphatic and aromatic aldehydes. The chemistry relies on the use of the highly efficient and substrate‐selective imidodiphosphorimidate catalyst, which displays some of the features of enzymatic catalysis.