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Directed Evolution Empowered Redesign of Natural Proteins for the Sustainable Production of Chemicals and Pharmaceuticals
Author(s) -
Bornscheuer Uwe T.,
Hauer Bernhard,
Jaeger Karl Erich,
Schwaneberg Ulrich
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201812717
Subject(s) - biochemical engineering , business , laundry , production (economics) , sustainable production , variety (cybernetics) , industrial production , microbiology and biotechnology , engineering , computer science , biology , waste management , economics , macroeconomics , artificial intelligence , keynesian economics
Abstract Directed evolution has advanced into a standard industrial “tool” to tailor naturally occurring proteins for a variety of biotechnological applications, thus enabling product valorization and bringing societal benefits across industrial sectors. Examples are sustainable enzymatic production processes for chemicals, pharmaceuticals, or applications in the food, feed, and laundry industries. In essence, directed evolution has contributed to sustainable industrial processes that fuel the transition from a fossil‐based economy to a biobased economy utilizing renewable resources. Phage display technologies represent a comparable breakthrough that allow for the directed evolution of binding proteins by physical coupling between a phenotype and the respective genotype, thus enabling the identification of highly selective antibodies for a broad variety of applications in diagnostics and therapy.