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Copper‐Catalyzed Asymmetric Arylation of N ‐Heteroaryl Aldimines: Elementary Step of a 1,4‐Insertion
Author(s) -
Wu Chunlin,
Qin Xurong,
Moeljadi Adhitya Mangala Putra,
Hirao Hajime,
Zhou Jianrong Steve
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201812646
Subject(s) - aldimine , copper , chemistry , denticity , catalysis , aryl , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , crystal structure , alkyl
Copper complexes of monodentate phosphoramidites efficiently promote asymmetric arylation of N ‐azaaryl aldimines with arylboroxines. DFT calculations and experiments support an elementary step of 1,4‐insertion in the reaction pathway, a step in which an aryl‐copper species adds directly across four atoms of C=N−C=N in the N ‐azaaryl aldimines.
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