Premium
Cover Picture: An Electrophilic Bromine Redox Catalysis for the Synthesis of Indole Alkaloid Building Blocks by Selective Aliphatic C−H Amination (Angew. Chem. Int. Ed. 48/2018)
Author(s) -
Bergès Julien,
García Belén,
Muñiz Kilian
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201812503
Subject(s) - amination , chemistry , bromine , catalysis , counterion , polymer chemistry , redox , organic chemistry , ion
A giant step forward for bromine redox catalysis that enables intermolecular C−H amination reactions at previously inaccessible aliphatic positions is described by K. Muñiz et al. in their Communication on page 15891 ff. The approach is based on the formation of anionic bromine(I) catalysts by the stoichiometric oxidation of ammonium bromides with a bisphthalimidato iodine(III) oxidant. Crystal structures of the catalysts reveal the bulky ammonium counterions to have a shape that is comparable to Giacometti′s famous bronze sculpture L ′homme qui marche .