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Palladium‐Catalyzed Intermolecular Aryliodination of Internal Alkynes
Author(s) -
Lee Yong Ho,
Morandi Bill
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201812396
Subject(s) - palladium , catalysis , alkyne , intermolecular force , aryl , chemistry , iodide , denticity , ligand (biochemistry) , combinatorial chemistry , organic chemistry , molecule , alkyl , crystal structure , biochemistry , receptor
A completely atom economical palladium‐catalyzed addition reaction has been developed to stereoselectively access functionalized tetrasubstituted alkenyl iodides. The palladium catalyst, which bears an electron‐poor bidentate ligand rarely employed in catalysis, is essential to promote the high yielding and chemoselective intermolecular reaction between equimolar amounts of an alkyne and an aryl iodide. This new carbohalogenation reaction is an attractive alternative to traditional synthetic methods, which rely on multistep synthetic sequences and protecting‐group manipulations.