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Enantioselective Oxidative Cyclization/Mannich Addition Enabled by Gold(I)/Chiral Phosphoric Acid Cooperative Catalysis
Author(s) -
Wei Hanlin,
Bao Ming,
Dong Kuiyong,
Qiu Lihua,
Wu Bing,
Hu Wenhao,
Xu Xinfang
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201812140
Subject(s) - enantioselective synthesis , alkyne , chemistry , catalysis , phosphoric acid , carbene , mannich reaction , combinatorial chemistry , triple bond , organic chemistry , medicinal chemistry , double bond
An enantioselective Mannich‐type reaction of 3‐butynol and nitrones is described, which affords dihydrofuran‐3‐ones in good yields and with excellent enantioselectivities. The reaction is initiated by gold‐catalyzed alkyne oxidation and modification of the resulting gold carbene species with a tethered hydroxy group to form enolate species; the reaction terminates with an enantioselective Mannich‐type addition with the assistance of chiral phosphoric acid (CPA) and hydrogen bonding. This novel pattern of alkyne transformation involving chemical bond cleavage, and a fragment modification and reassembly process, provides an atom‐ and step‐economic method, and is the first example of cooperative asymmetric catalysis in gold‐catalyzed alkyne oxidations via an α‐oxo gold carbene route.