Premium
Reusable Nickel Nanoparticles‐Catalyzed Reductive Amination for Selective Synthesis of Primary Amines
Author(s) -
Murugesan Kathiravan,
Beller Matthias,
Jagadeesh Rajenahally V.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201812100
Subject(s) - reductive amination , amination , catalysis , nickel , primary (astronomy) , chemistry , moiety , combinatorial chemistry , ammonia , organic chemistry , pyrolysis , nanoparticle , tartaric acid , materials science , nanotechnology , physics , astronomy , citric acid
The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni‐tartaric acid complex on silica is presented. The resulting stable and reusable Ni‐nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of molecular hydrogen. Applying this Ni‐based amination protocol, ‐NH 2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.