Inside Cover: Adenine‐Driven Structural Switch from a Two‐ to Three‐Quartet DNA G‐Quadruplex (Angew. Chem. Int. Ed. 47/2018) | Zendy

Lenarčič Živković Martina | Zendy; Rozman Jan | Zendy; Plavec Janez | Zendy

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Inside Cover: Adenine‐Driven Structural Switch from a Two‐ to Three‐Quartet DNA G‐Quadruplex (Angew. Chem. Int. Ed. 47/2018)

Author(s) -

Lenarčič Živković Martina,

Rozman Jan,

Plavec Janez

Publication year - 2018

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201811824

Subject(s) - g quadruplex , folding (dsp implementation) , loop (graph theory) , dna , int , cover (algebra) , chemistry , stereochemistry , sequence (biology) , biophysics , biology , computer science , combinatorics , biochemistry , mathematics , engineering , mechanical engineering , electrical engineering , operating system

Specific loop interactions involving an adenine residue can critically influence the folding pathway and structure of a G‐quadruplex. In their Communication on page 15395 ff., J. Plavec and co‐workers show that a sequence with four GGG‐tracts folds into a G‐quadruplex with two quartets stabilized by A⋅G⋅A and G⋅G⋅G base‐triads. Modification of a single adenine modulates the loop interactions and leads to exciting structural changes including a two‐to‐three‐quartet structural switch.

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