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Inside Cover: Adenine‐Driven Structural Switch from a Two‐ to Three‐Quartet DNA G‐Quadruplex (Angew. Chem. Int. Ed. 47/2018)
Author(s) -
Lenarčič Živković Martina,
Rozman Jan,
Plavec Janez
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201811824
Subject(s) - g quadruplex , folding (dsp implementation) , loop (graph theory) , dna , int , cover (algebra) , chemistry , stereochemistry , sequence (biology) , biophysics , biology , computer science , combinatorics , biochemistry , mathematics , engineering , mechanical engineering , electrical engineering , operating system
Specific loop interactions involving an adenine residue can critically influence the folding pathway and structure of a G‐quadruplex. In their Communication on page 15395 ff., J. Plavec and co‐workers show that a sequence with four GGG‐tracts folds into a G‐quadruplex with two quartets stabilized by A⋅G⋅A and G⋅G⋅G base‐triads. Modification of a single adenine modulates the loop interactions and leads to exciting structural changes including a two‐to‐three‐quartet structural switch.