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A Dual‐Targeted Organic Photothermal Agent for Enhanced Photothermal Therapy
Author(s) -
Wang Hongyu,
Chang Jinjie,
Shi Mingwan,
Pan Wei,
Li Na,
Tang Bo
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201811273
Subject(s) - photothermal therapy , cytotoxicity , in vivo , cancer therapy , nanotechnology , targeted therapy , cancer cell , cancer research , photothermal effect , materials science , chemistry , cancer , in vitro , biology , medicine , biochemistry , microbiology and biotechnology
The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues is a challenging topic in cancer therapy. Herein, we demonstrate a dual‐targeted organic molecule that functions as a photothermal agent by actively targeting tumor tissue and mitochondria to selectively kill cancer cells. The synthesized photothermal agent exhibited high photothermal conversion efficiency, low cytotoxicity, and good biological compatibility. In vivo experiments showed an excellent tumor inhibitory effect of the dual‐targeted photothermal agent.