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Platinum‐Catalyzed Desaturation of Lactams, Ketones, and Lactones
Author(s) -
Chen Ming,
Rago Alexander J.,
Dong Guangbin
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201811197
Subject(s) - catalysis , chemistry , platinum , palladium , reactivity (psychology) , bromide , iodide , sulfur , conjugated system , combinatorial chemistry , ketone , organic chemistry , medicine , polymer , alternative medicine , pathology
The development of a general platinum‐catalyzed desaturation of N‐protected lactams, ketones, and lactones to their conjugated α,β‐unsaturated counterparts is reported. The reaction operates under mildly acidic conditions at room temperature or 50 °C. It is scalable and tolerates a wide range of functional groups. The complementary reactivity to the palladium‐catalyzed desaturation is demonstrated in the efficient conversion of iodide, bromide, and sulfur‐containing substrates.