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Palladium‐Catalyzed Decarbonylative Difluoromethylation of Acid Chlorides at Room Temperature
Author(s) -
Pan Fei,
Boursalian Gregory B.,
Ritter Tobias
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201811139
Subject(s) - reagent , palladium , catalysis , chemistry , decarbonylation , zinc , functional group , organic chemistry , combinatorial chemistry , polymer
Methods for the direct synthesis of difluoromethylated arenes are sparse, despite the importance of the difluoromethyl group in medical, agro‐, and materials chemistry. A palladium‐catalyzed decarbonylative cross‐coupling reaction of acid chlorides with a difluoromethyl zinc reagent is achieved to access difluoromethylated compounds. The transformation proceeds at room temperature and shows broad functional group tolerance, thus providing a general and efficient method for decarbonylative difluoromethylation of a wide range of aromatic carboxylic acids.