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Chemoselective Pd‐Catalyzed C‐TeCF 3 Coupling of Aryl Iodides
Author(s) -
Sperger Theresa,
Guven Sinem,
Schoenebeck Franziska
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201810950
Subject(s) - xantphos , aryl , catalysis , moiety , combinatorial chemistry , chemistry , transformation (genetics) , coupling (piping) , palladium , stereochemistry , materials science , organic chemistry , alkyl , metallurgy , biochemistry , gene
While the TeCF 3 moiety features promising properties and potential in a range of applications, no direct synthetic method exists for its incorporation into aromatic scaffolds. This report features the first direct catalytic method for the formation of C(sp 2 )−TeCF 3 bonds. The method relies on a Pd/Xantphos catalytic system and allows for the trifluoromethyltellurolation of aryl iodides. Our computational and experimental mechanistic analyses shed light on the privileged activity of Xantphos in this transformation.