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Covalent Organic Frameworks with Chirality Enriched by Biomolecules for Efficient Chiral Separation
Author(s) -
Zhang Sainan,
Zheng Yunlong,
An Hongde,
Aguila Briana,
Yang ChengXiong,
Dong Yueyue,
Xie Wei,
Cheng Peng,
Zhang Zhenjie,
Chen Yao,
Ma Shengqian
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201810571
Subject(s) - biomolecule , chirality (physics) , covalent bond , chemistry , combinatorial chemistry , organic chemistry , biochemistry , chiral symmetry , physics , quantum mechanics , nambu–jona lasinio model , quark
The separation of racemic compounds is important in many fields, such as pharmacology and biology. Taking advantage of the intrinsically strong chiral environment and specific interactions featured by biomolecules, here we contribute a general strategy is developed to enrich chirality into covalent organic frameworks (COFs) by covalently immobilizing a series of biomolecules (amino acids, peptides, enzymes) into achiral COFs. Inheriting the strong chirality and specific interactions from the immobilized biomolecules, the afforded biomolecules⊂COFs serve as versatile and highly efficient chiral stationary phases towards various racemates in both normal and reverse phase of high‐performance liquid chromatography (HPLC). The different interactions between enzyme secondary structure and racemates were revealed by surface‐enhanced Raman scattering studies, accounting for the observed chiral separation capacity of enzymes⊂COFs.