The Combination of Benzaldehyde and Nickel‐Catalyzed Photoredox C(sp 3 )−H Alkylation/Arylation | Zendy

Zhang Lumin | Zendy; Si Xiaojia | Zendy; Yang Yangyang | Zendy; Zimmer Marc | Zendy; Witzel Sina | Zendy; Sekine Kohei | Zendy; Rudolph Matthias | Zendy; Hashmi A. Stephen K. | Zendy

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The Combination of Benzaldehyde and Nickel‐Catalyzed Photoredox C(sp 3 )−H Alkylation/Arylation

Author(s) -

Zhang Lumin,

Si Xiaojia,

Yang Yangyang,

Zimmer Marc,

Witzel Sina,

Sekine Kohei,

Rudolph Matthias,

Hashmi A. Stephen K.

Publication year - 2019

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201810526

Subject(s) - alkylation , benzaldehyde , nickel , catalysis , chemistry , photoredox catalysis , metal , transition metal , organic chemistry , combinatorial chemistry , photocatalysis

Herein we report a highly selective photoredox C(sp 3 )−H alkylation/arylation of ethers through the combination of a photo‐organocatalyst (benzaldehyde) and a transition‐metal catalyst (nickel). This method provides a simple and general strategy for the C(sp 3 )−H alkylation/arylation of ethers. A selective late‐stage modification of (−)‐ambroxide has also been conducted to demonstrate the applicability of the method.

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