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The Combination of Benzaldehyde and Nickel‐Catalyzed Photoredox C(sp 3 )−H Alkylation/Arylation
Author(s) -
Zhang Lumin,
Si Xiaojia,
Yang Yangyang,
Zimmer Marc,
Witzel Sina,
Sekine Kohei,
Rudolph Matthias,
Hashmi A. Stephen K.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201810526
Subject(s) - alkylation , benzaldehyde , nickel , catalysis , chemistry , photoredox catalysis , metal , transition metal , organic chemistry , combinatorial chemistry , photocatalysis
Herein we report a highly selective photoredox C(sp 3 )−H alkylation/arylation of ethers through the combination of a photo‐organocatalyst (benzaldehyde) and a transition‐metal catalyst (nickel). This method provides a simple and general strategy for the C(sp 3 )−H alkylation/arylation of ethers. A selective late‐stage modification of (−)‐ambroxide has also been conducted to demonstrate the applicability of the method.