Premium
Palladium‐Catalyzed Intermolecular Arylcarbonylation of Unactivated Alkenes: Incorporation of Bulky Aryl Groups at Room Temperature
Author(s) -
Li Xiang,
Chen Pinhong,
Liu Guosheng
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201810405
Subject(s) - regioselectivity , aryl , palladium , chemistry , intermolecular force , catalysis , functional group , reagent , double bond , medicinal chemistry , organic chemistry , combinatorial chemistry , molecule , alkyl , polymer
A palladium‐catalyzed intermolecular arylcarbonylation of unactivated alkenes has been developed. Unsymmetrical diaryliodonium salts (DAISs) were used as arylation reagents, the bulky aryl group ( Ar L ) of which was exclusively incorporated into the arylcarbonylated products, which contained the Ar L group and a carboxylic ester group at the α‐ and β‐carbon position, respectively, of the original terminal C−C double bond. The reaction features excellent chemo‐ and regioselectivity, high functional‐group tolerance, and very mild reaction conditions.