Premium
Digging into the Sequential Space of Thiolactone Precision Polymers: A Combinatorial Strategy to Identify Functional Domains
Author(s) -
Celasun Sensu,
Remmler Dario,
Schwaar Timm,
Weller Michael G.,
Du Prez Filip,
Börner Hans G.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201810393
Subject(s) - thiolactone , payload (computing) , combinatorial chemistry , polymer , diamondoid , nanotechnology , conjugate , computer science , bead , chemistry , materials science , stereochemistry , molecule , organic chemistry , mathematics , computer network , mathematical analysis , network packet , composite material
Functional sequences of precision polymers based on thiolactone/Michael chemistry are identified from a large one‐bead one‐compound library. Single‐bead readout by MALDI‐TOF MS/MS identifies sequences that host m ‐THPC that is a second generation photo‐sensitizer drug. The corresponding Tla/Michael‐PEG conjugates make m ‐THPC available in solution and drug payload as well as drug release kinetics can be fine‐tuned by the precision segment.