Digging into the Sequential Space of Thiolactone Precision Polymers: A Combinatorial Strategy to Identify Functional Domains | Zendy

Celasun Sensu | Zendy; Remmler Dario | Zendy; Schwaar Timm | Zendy; Weller Michael G. | Zendy; Du Prez Filip | Zendy; Börner Hans G. | Zendy

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Digging into the Sequential Space of Thiolactone Precision Polymers: A Combinatorial Strategy to Identify Functional Domains

Author(s) -

Celasun Sensu,

Remmler Dario,

Schwaar Timm,

Weller Michael G.,

Du Prez Filip,

Börner Hans G.

Publication year - 2019

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201810393

Subject(s) - digging , thiolactone , space (punctuation) , computer science , nanotechnology , chemistry , materials science , geography , archaeology , stereochemistry , operating system

Functional sequences of precision polymers based on thiolactone/Michael chemistry are identified from a large one‐bead one‐compound library. Single‐bead readout by MALDI‐TOF MS/MS identifies sequences that host m ‐THPC that is a second generation photo‐sensitizer drug. The corresponding Tla/Michael‐PEG conjugates make m ‐THPC available in solution and drug payload as well as drug release kinetics can be fine‐tuned by the precision segment.

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