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Inside Cover: Regioselective Metal‐ and Reagent‐Free Arylation of Benzothiophenes by Dehydrogenative Electrosynthesis (Angew. Chem. Int. Ed. 40/2018)
Author(s) -
Lips Sebastian,
Schollmeyer Dieter,
Franke Robert,
Waldvogel Siegfried R.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201810303
Subject(s) - electrosynthesis , reagent , regioselectivity , chemistry , catalysis , combinatorial chemistry , stoichiometry , electrochemistry , organic chemistry , electrode
Electrochemical “welding” serves as a powerful tool for the arylation of benzo[ b ]thiophenes in position 2 or 3. S. R. Waldvogel and co‐workers report in their Communication on page 13325 ff. the first electro‐organic dehydrogenative synthesis of 2‐ or 3‐(hydroxyphenyl)benzo[ b ]thiophenes by oxidative cross‐coupling reactions. The direct use of electricity as a reagent eliminates the necessity of leaving groups, metal catalysts, stoichiometric oxidizers, or reducing agents. Therefore, the reaction enables a sustainable synthetic pathway to these scaffolds and can be considered as ”green chemistry”.