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Inside Cover: Rationally Designed Peptidyl Virus‐Like Particles Enable Targeted Delivery of Genetic Cargo (Angew. Chem. Int. Ed. 43/2018)
Author(s) -
Kong Jia,
Wang Yuefei,
Zhang Jiaxing,
Qi Wei,
Su Rongxin,
He Zhimin
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201810299
Subject(s) - virus , cover (algebra) , gene delivery , nanotechnology , virology , computational biology , chemistry , biology , gene , genetics , materials science , genetic enhancement , engineering , mechanical engineering
Virus‐like particles that mimic the structure and functions of natural viruses have promising applications in gene therapy. In their Communication on page 14032 ff., Y. Wang, W. Qi, et al. report a strategy to construct peptidyl virus‐like particles (pVLPs). They designed two self‐assembling peptides based on HIV and simian virus 40 sequences. These peptides can enclose DNA to form biodegradable pVLPs with excellent cell‐targeting ability for the nuclear delivery of genetic cargo.