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A Catalytic Cross‐Olefination of Diazo Compounds with Sulfoxonium Ylides
Author(s) -
Neuhaus James D.,
Bauer Adriano,
Pinto Alexandre,
Maulide Nuno
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201809934
Subject(s) - diazo , carbene , nucleophile , reactivity (psychology) , ruthenium , catalysis , chemistry , organic chemistry , combinatorial chemistry , medicine , alternative medicine , pathology
A ruthenium‐catalysed cross‐olefination of diazo compounds and sulfoxonium ylides is presented. Our reaction design exploits the intrinsic difference in reactivity of diazo compounds and sulfoxonium ylides as both carbene precursors and nucleophiles, which results in a highly selective reaction.