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Selective C−N Borylation of Alkyl Amines Promoted by Lewis Base
Author(s) -
Hu Jiefeng,
Wang Guoqiang,
Li Shuhua,
Shi Zhuangzhi
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201809608
Subject(s) - borylation , chemistry , alkyl , lewis acids and bases , pyridinium , alkene , medicinal chemistry , amine gas treating , boron , electrophile , reactivity (psychology) , organic chemistry , combinatorial chemistry , catalysis , aryl , medicine , alternative medicine , pathology
An efficient method for the metal‐free deaminative borylation of alkylamines, using bis(catecholato)diboron as the boron source, to directly synthesize various alkyl potassium trifluoroborate salts is introduced. The key to this high reactivity is the utilization of pyridinium salt activated alkylamines, with a catalytic amount of a bipyridine‐type Lewis base as a promoter. This transformation shows good functional‐group compatibility (e.g., it is unimpeded by the presence of a ketone, indole, internal alkene, or unactivated alkyl chloride) and can serve as a powerful synthetic tool for borylation of amine groups in complex compounds. Mechanistic experiments and computations suggest a mechanism in which the Lewis base activated B 2 cat 2 unit intercepts an alkyl radical generated by single‐electron transfer (SET) from a boron‐based reductant.