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Array‐based “Chemical Nose” Sensing in Diagnostics and Drug Discovery
Author(s) -
Geng Yingying,
Peveler William J.,
Rotello Vincent M.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201809607
Subject(s) - electronic nose , computer science , drug discovery , analyte , sensor array , identification (biology) , nanotechnology , chemical sensor , computational biology , artificial intelligence , bioinformatics , machine learning , biology , materials science , chemistry , botany , electrode
Array‐based sensor “chemical nose/tongue” platforms are inspired by the mammalian olfactory system. Multiple sensor elements in these devices selectively interact with target analytes, producing a distinct pattern of response and enabling analyte identification. This approach offers unique opportunities relative to “traditional” highly specific sensor elements such as antibodies. Array‐based sensors excel at distinguishing small changes in complex mixtures, and this capability is being leveraged for chemical biology studies and clinical pathology, enabled by a diverse toolkit of new molecular, bioconjugate and nanomaterial technologies. Innovation in the design and analysis of arrays provides a robust set of tools for advancing biomedical goals, including precision medicine.