Premium
Meisenheimer Complexes in S N Ar Reactions: Intermediates or Transition States?
Author(s) -
Lennox Alastair J. J.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201809606
Subject(s) - transition state , chemistry , transition (genetics) , photochemistry , chemical physics , computational chemistry , catalysis , organic chemistry , biochemistry , gene
Meisenheimer's missing ! Anionic σ‐complexes, best known as Meisenheimer complexes, have long been assumed to be intermediates in S N Ar reactions. New evidence now suggests that these intermediates may only be formed in select cases and that a concerted pathway is more common. These claims are supported by 12 C/ 13 C kinetic isotopes effects, determined using a new method based on 19 F NMR, and DFT calculations.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom