Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server | Zendy

Fitzpatrick Daniel E. | Zendy; Maujean Timothé | Zendy; Evans Amanda C. | Zendy; Ley Steven V. | Zendy

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Across‐the‐World Automated Optimization and Continuous‐Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud‐Based Server

Author(s) -

Fitzpatrick Daniel E.,

Maujean Timothé,

Evans Amanda C.,

Ley Steven V.

Publication year - 2018

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201809080

Subject(s) - cloud computing , continuous flow , flow chemistry , computer science , flow (mathematics) , operating system , biochemical engineering , engineering , mathematics , geometry

The power of the Cloud has been harnessed for pharmaceutical compound production with remote servers based in Tokyo, Japan being left to autonomously find optimal synthesis conditions for three active pharmaceutical ingredients (APIs) in laboratories in Cambridge, UK. A researcher located in Los Angeles, USA controlled the entire process via an internet connection. The constituent synthetic steps for Tramadol, Lidocaine, and Bupropion were thus optimized with minimal intervention from operators within hours, yielding conditions satisfying customizable evaluation functions for all examples.

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